NDD w/o Epilepsy
Explore NDD without Epilepsy (NDDwoE), a unique SCN8A phenotype marked by developmental delays minus the seizures, highlighting a path of hopeful progress.
Neurodevelopmental Disorder (NDD) without Epilepsy
NDD without epilepsy involves developmental delays and cognitive challenges absent seizure activity. Children with this condition may struggle with motor skills, speech, and learning but have a better prognosis for improvement compared to more severe variants. Improvements in these areas are possible over time, especially with early intervention and support. Behavioral and emotional regulation issues are also common but may stabilize or improve as the child develops. This condition presents a unique set of challenges, yet with a hopeful outlook for progress and adaptation.
| Seizure Onset | N/A | |
| Developmental Delay Onset | 12 - 36 Months | |
| Seizure Types | None | |
| Clinical Features | Delayed Motor Abilities and Language, Some Cognitive Understanding, Autistic Features | |
| Seizure Freedom | N/A | |
| Prognosis | Limited Change to Improvement |
Seizure Onset
N/A
Developmental Delay Onset
12 – 36 Months
Seizure Types
None
Clinical Features
Delayed Motor Abilities and Language, Some Cognitive Understanding, Autistic Features
Seizure Freedom
N/A
Prognosis
Limited Change to Improvement
Clincal Features
This table shows consensus levels for severity and expected change over time among common comorbidities. Compared with severe DEE, NDD without generalized epilepsy consensus showed less severity than severe DEE for all comorbidities except sleep disturbances and autism spectrum disorder. There were many areas where comorbidity progression was similar or worse than severe DEE. Most of these are neurological or cognitive comorbidities.
Prognosis
Both cognition and development are expected to develop with limited change or moderate improvement. Both areas have moderate consensus.
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IMPORTANT: While this consensus data provides new and valuable insights about best practices in the diagnosis and treatment of SCN8A, this is not medical advice. It can inform clinicians and caregivers alike in developing optimal treatment plans for each individual.